Hepatoprotective species from the Chilean medicinal flora: <i>Junellia spathulata</i> (Verbenaceae)

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dc.contributor.authorBridi, Raquel
dc.contributor.authorvon Poser, Gilsane Lino
dc.contributor.authorGomez, Miguel
dc.contributor.authorAndia, Marcelo E.
dc.contributor.authorEsteban Oyarzun, Juan
dc.contributor.authorNunenz, Paula
dc.contributor.authorVasquez Arias, Ariadsna Jael
dc.contributor.authorEspinosa-Bustos, Christian
dc.date.accessioned2025-01-20T23:54:47Z
dc.date.available2025-01-20T23:54:47Z
dc.date.issued2021
dc.description.abstractEthnopharmacological relevance: Chilean population relies on medicinal plants for treating a wide range of illnesses, especially those of the gastrointestinal system. Junellia spathulata (Gillies & Hook.) Moldenke var. spathulata (Verbenaceae), called as "verbena-azul-de-cordilleira", is a medicinal plant native to Argentina and Chile traditionally used for treating digestive disorders. Although the species of the genus ar e important as therapeutic resources for the Andean population, the plants are ver y scarcely studied.
dc.description.abstractAims of the study: The purpose of the present study was to find out the main constituents and investigate the protective effect of J. spathulata against oxidative stress induced by the potent oxidant 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH) in human hepatoblastoma cells.
dc.description.abstractMaterials and methods: The crude methanol extract of J. spathulata and an iridoid obtained by chromatographic processes were tested to access the hepatoprotective effect and cytotoxicity in HepG2 cell. In addition, the reducing power of the samples and their ability to scavenge free radicals were evaluated using FRAP and ORAC assay systems.
dc.description.abstractResults: The iridoid asperuloside, the main compound of the crude methanol extract ofJ. spathulata, was isolated and identified by means of NMR analysis. The crude methanol extract ofJ. spathulata and asperuloside protected HepG2 cells against oxidative damage triggered by AAPH-derived free radicals. This effect can be credited to the ability of the extract and asperuloside to protect the liver cells from chemical-induced injury, which might be correlated to their free radical scavenging potential.
dc.description.abstractConclusions: This study experimentally evidenced the ethnopharmacological usefulness of J. spathulata as a treatment of digestive disorders. Ou r result coul d stimulate further investigations of hepatoprotective agents in other Chilean Junellia species.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jep.2020.113543
dc.identifier.eissn1872-7573
dc.identifier.issn0378-8741
dc.identifier.urihttps://doi.org/10.1016/j.jep.2020.113543
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95049
dc.identifier.wosidWOS:000606378200004
dc.language.isoen
dc.revistaJournal of ethnopharmacology
dc.rightsacceso restringido
dc.subjectChilean native species
dc.subjectJunellia spathulata
dc.subjectVerbenaceae
dc.subjectHepatoprotection
dc.subjectIridoid
dc.subjectAsperuloside
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHepatoprotective species from the Chilean medicinal flora: <i>Junellia spathulata</i> (Verbenaceae)
dc.typeartículo
dc.volumen267
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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