Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat

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dc.contributor.authorOliveri, C
dc.contributor.authorOcaranza, MP
dc.contributor.authorCampos, X
dc.contributor.authorLavandero, S
dc.contributor.authorJalil, JE
dc.date.accessioned2024-01-10T13:45:52Z
dc.date.available2024-01-10T13:45:52Z
dc.date.issued2001
dc.description.abstractAngiotensin I is a substrate for both ACE and for neutral endopeptidase 24.11 (NEP). We hypothesized that high ACE expression is related to low NEP activity. Accordingly, circulating and tissue NEP and ACE activities were measured by fluorometry in homozygous rats (FO and 172) for the Lewis microsatellite allele (LL, low ACE) and for the Brown Norway microsatellite allele (BB, high ACE). Plasma, lung, and aortic ACE activities in F-0 and F-2 were higher in BB rats than in LL rats (P <0.01), whereas left ventricular ACE activity was similar in both genotypes. In contrast, NEP activity in the LL group was higher in the serum, aorta, and lungs in F-0 and F-2 homozygous (P <0.05). Plasma ACE activity was inversely correlated with serum (r=-0.6 and -0.598 in F-0 and F-2, respectively; P <0.03) and lung NEP activities (r=-0.77 in F-0 and r=-0.59 in F-2, P <0.01). Aortic ACE and NEP activities were also correlated (r=-0.696 and -0.584 in F-0 and F-2, respectively; P <0.03). In conclusion, genetically determined high ACE expression in rats is inversely related to tissue NEP activity, which could determine lower angiotensin-(1-7) tissue levels.
dc.fechaingreso.objetodigital2024-05-20
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1161/hy0901s1.095011
dc.identifier.eissn1524-4563
dc.identifier.issn0194-911X
dc.identifier.pubmedidMEDLINE:11566949
dc.identifier.urihttps://doi.org/10.1161/hy0901s1.095011
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79090
dc.identifier.wosidWOS:000171308400024
dc.information.autorucMedicina;Jalil J;S/I;99946
dc.information.autorucMedicina;Ocaranza M;S/I;1001254
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final654
dc.pagina.inicio650
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaHYPERTENSION
dc.rightsacceso restringido
dc.subjectangiotensin-converting enzyme
dc.subjectangiotensin
dc.subjectpolymorphism
dc.subjectneutral endopeptidase
dc.subjectSENSITIVE FLUOROMETRIC ASSAY
dc.subjectBLOOD-PRESSURE
dc.subjectGENETIC-LINKAGE
dc.subjectVIVO METABOLISM
dc.subjectPLASMA
dc.subjectENKEPHALINASE
dc.subjectPOLYMORPHISM
dc.subjectEXPRESSION
dc.subjectBRADYKININ
dc.subjectLOCUS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAngiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat
dc.typeartículo
dc.volumen38
sipa.codpersvinculados99946
sipa.codpersvinculados1001254
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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