Long term platinum-induced ototoxicity in pediatric patients

Simple item page
dc.contributor.authorWaissbluth, Sofia
dc.contributor.authorChuang, Angela
dc.contributor.authorDel Valle, Alvaro
dc.contributor.authorCordova, Marcela
dc.date.accessioned2025-01-23T21:22:54Z
dc.date.available2025-01-23T21:22:54Z
dc.date.issued2018
dc.description.abstractObjectives: Platinum-based chemotherapy treatments are effective against a variety of pediatric malignancies. However, its use can lead to permanent hearing loss. The aim of this study was to evaluate the long-term effect of platinum chemotherapy on hearing and evaluate its progression.
dc.description.abstractMethods: Prospective cohort study. All records of pediatric patients receiving platinum-based chemotherapy between 2001 and 2006 were reviewed. Demographics and audiograms performed before, during, and following chemotherapy were analyzed. An updated audiogram and a video head impulse test were performed. A hearing ability questionnaire was also completed.
dc.description.abstractResults: Thirty-nine patients met the inclusion criteria. Of these, 12 patients were included in the study; 14 were deceased, 8 had incomplete data and 5 were excluded for other reasons. Median age at chemotherapy was 4.3 years (range 10 months-14.2 years). Seven patients had received cisplatin, two received carboplatin and three received both agents. Five had also received cranial irradiation. With a median follow-up time of 11.9 years, 58.3% had developed hearing loss and two patients wore bilateral hearing aids; 67% of the patients with hearing loss had worsening of their hearing in the long-term. All patients referred difficulties in various subscales measured by the questionnaire. Three patients had decreased vestibulo-ocular reflex gains.
dc.description.abstractConclusion: Platinum-induced hearing loss in pediatric patients can be progressive and debilitating. A long term audiometric follow-up of at least 10 years is suggested for these patients.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ijporl.2018.01.028
dc.identifier.eissn1872-8464
dc.identifier.issn0165-5876
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2018.01.028
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101267
dc.identifier.wosidWOS:000428492100015
dc.language.isoen
dc.pagina.final79
dc.pagina.inicio75
dc.revistaInternational journal of pediatric otorhinolaryngology
dc.rightsacceso restringido
dc.subjectPlatinum
dc.subjectCisplatin
dc.subjectHearing loss
dc.subjectOtotoxicity
dc.subjectProgression
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLong term platinum-induced ototoxicity in pediatric patients
dc.typeartículo
dc.volumen107
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas