Role of astrocytes connexins - pannexins in acute brain injury

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dc.catalogadorjlo
dc.contributor.authorTichauer Calderón, Juan Enrique
dc.contributor.authorRovegno Echavarría, David Maximiliano
dc.date.accessioned2025-02-27T18:33:43Z
dc.date.available2025-02-27T18:33:43Z
dc.date.issued2025
dc.description.abstractAcute brain injuries (ABIs) encompass a broad spectrum of primary injuries such as ischemia, hypoxia, trauma, and hemorrhage that converge into secondary injury where some mechanisms show common determinants. In this regard, astroglial connexin and pannexin channels have been shown to play an important role. These channels are transmembrane proteins sharing similar topology and form gateways between adjacent cells named gap junctions (GJs) and pores into unopposed membranes named hemichannels (HCs). In astrocytes, GJs and HCs enable intercellular communication and have active participation in normal brain physiological processes, such as calcium waves, synapsis modulation, regional blood flow regulation, and homeostatic control of the extracellular environment, among others. However, after acute brain injury, astrocytes can change their phenotype and modify the activity of both channels and hemichannels, which can result in the amplification of danger signals, increased mediators of inflammation, and neuronal death, contributing to the expansion of brain damage and neurological deterioration. This is known as secondary brain damage. In this review, we discussed the main biological mechanism of secondary brain damage with a particular focus on astroglial connexin and pannexin participation during acute brain injuries.
dc.format.extent17 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.1016/j.neurot.2025.e00523
dc.identifier.issn1878-7479
dc.identifier.urihttps://doi.org/10.1016/j.neurot.2025.e00523
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102280
dc.information.autorucEscuela de Medicina; Tichauer Calderón, Juan Enrique; S/I; 1492
dc.information.autorucEscuela de Medicina; Rovegno Echavarría, David Maximiliano; 0000-0002-2882-8024; 1004053
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaNeurotherapeutics
dc.rightsacceso restringido
dc.rights.licenseCC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAstrocyte
dc.subjectConnexins
dc.subjectPannexins
dc.subjectHemichannels
dc.subjectAcute brain injury
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleRole of astrocytes connexins - pannexins in acute brain injury
dc.typeartículo
dc.volumen22
sipa.codpersvinculados1492
sipa.codpersvinculados1004053
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