A Role for the Insular Cortex in Long-Term Memory for Context-Evoked Drug Craving in Rats

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dc.contributor.authorContreras, Marco
dc.contributor.authorBilleke, Pablo
dc.contributor.authorVicencio, Sergio
dc.contributor.authorMadrid, Carlos
dc.contributor.authorPerdomo, Gueton
dc.contributor.authorGonzalez, Marcela
dc.contributor.authorTorrealba, Fernando
dc.date.accessioned2025-01-20T23:57:29Z
dc.date.available2025-01-20T23:57:29Z
dc.date.issued2012
dc.description.abstractDrug craving critically depends on the function of the interoceptive insular cortex, and may be triggered by contextual cues. However, the role of the insula in the long-term memory linking context with drug craving remains unknown. Such a memory trace probably resides in some neocortical region, much like other declarative memories. Studies in humans and rats suggest that the insula may include such a region. Rats chronically implanted with bilateral injection cannulae into the high-order rostral agranular insular cortex (RAIC) or the primary interoceptive posterior insula (pIC) were conditioned to prefer the initially aversive compartment of a 2-compartment place preference apparatus by repeatedly pairing it to amphetamine. We found a reversible but long-lasting loss (ca. 24 days) of amphetamine-conditioned place preference (CPP) and a decreased expression in the insula of zif268, a crucial protein in memory reconsolidation, when anisomycin (ANI) was microinjected into the RAIC immediately after the reactivation of the conditioned amphetamine/context memory. ANI infusion into the RAIC without reactivation did not change CPP, whereas ANI infusion into pIC plus caused a 15 days loss of CPP. We also found a 24 days loss of CPP when we reversibly inactivated pIC during extinction trials. We interpret these findings as evidence that the insular cortex, including the RAIC, is involved in a context/drug effect association. These results add a drug-related memory function to the insular cortex to the previously found role of the pIC in the perception of craving or malaise. Neuropsychopharmacology (2012) 37, 2101-2108; doi:10.1038/npp.2012.59; published online 25 April 2012
dc.fuente.origenWOS
dc.identifier.doi10.1038/npp.2012.59
dc.identifier.issn0893-133X
dc.identifier.urihttps://doi.org/10.1038/npp.2012.59
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95208
dc.identifier.wosidWOS:000306494600013
dc.issue.numero9
dc.language.isoen
dc.pagina.final2108
dc.pagina.inicio2101
dc.revistaNeuropsychopharmacology
dc.rightsacceso restringido
dc.subjectaddiction
dc.subjectamphetamine
dc.subjectcraving
dc.subjectconditioned place preference
dc.subjectinsula
dc.subjectmemory reconsolidation
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA Role for the Insular Cortex in Long-Term Memory for Context-Evoked Drug Craving in Rats
dc.typeartículo
dc.volumen37
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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