Pannexin-1 channel opening is critical for COVID-19 pathogenesis

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dc.contributor.authorLuu, Ross
dc.contributor.authorValdebenito, Silvana
dc.contributor.authorScemes, Eliana
dc.contributor.authorCibelli, Antonio
dc.contributor.authorSpray, David C.
dc.contributor.authorRovegno, Maximiliano
dc.contributor.authorTichauer, Juan
dc.contributor.authorCottignies Calamarte, Andrea
dc.contributor.authorRosenberg, Arielle
dc.contributor.authorCapron, Calude
dc.contributor.authorBelouzard, Sandrine
dc.contributor.authorDubuisson, Jean
dc.contributor.authorAnnane, Djillali
dc.contributor.authorde la Grandmaison, Geoffroy Lorin
dc.contributor.authorCramer Borde, Elisabeth
dc.contributor.authorBomsel, Morgane
dc.contributor.authorEugenin, Eliseo
dc.date.accessioned2024-01-10T12:37:00Z
dc.date.available2024-01-10T12:37:00Z
dc.date.issued2021
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly rampaged worldwide, causing a pandemic of coronavirus disease (COVID-19), but the biology of SARS-CoV-2 remains under investigation. We demonstrate that both SARS-CoV-2 spike protein and human coronavirus 229E (hCoV-229E) or its purified S protein, one of the main viruses responsible for the common cold, induce the transient opening of Pannexin-1 (Panx-1) channels in human lung epithelial cells. However, the Panx-1 channel opening induced by SARS-CoV-2 is greater and more prolonged than hCoV-229E/S protein, resulting in an enhanced ATP, PGE(2), and IL-1 beta release. Analysis of lung lavages and tissues indicate that Panx-1 mRNA expression is associated with increased ATP, PGE(2), and IL-1 beta levels. Panx-1 channel opening induced by SARS-CoV-2 spike protein is angiotensin-converting enzyme 2 (ACE-2), endocytosis, and furin dependent. Overall, we demonstrated that Panx-1 channel is a critical contributor to SARS-CoV-2 infection and should be considered as an alternative therapy.
dc.description.funderNational Institutes of Health
dc.description.funderNational Institute of Neurological Disorders and Stroke
dc.description.funderUTMB internal funding
dc.description.funderANR
dc.description.funderFondation pour la Recherche Medicale
dc.fechaingreso.objetodigital26-03-2024
dc.format.extent28 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.isci.2021.103478
dc.identifier.eissn2589-0042
dc.identifier.pubmedidMEDLINE:34841222
dc.identifier.urihttps://doi.org/10.1016/j.isci.2021.103478
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76719
dc.identifier.wosidWOS:000740253300003
dc.information.autorucFacultad de Medicina; Rovegno Echavarria, David Maximiliano; S/I; 1004053
dc.issue.numero12
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherCELL PRESS
dc.revistaISCIENCE
dc.rightsacceso abierto
dc.subjectATP RELEASE
dc.subjectPURINERGIC RECEPTORS
dc.subjectEXTRACELLULAR ATP
dc.subjectCYSTIC-FIBROSIS
dc.subjectCONNEXIN HEMICHANNELS
dc.subjectLUNG INFLAMMATION
dc.subjectSPIKE PROTEIN
dc.subjectHIV-INFECTION
dc.subjectPLATELET
dc.subjectSARS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePannexin-1 channel opening is critical for COVID-19 pathogenesis
dc.typeartículo
dc.volumen24
sipa.codpersvinculados1004053
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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