Immune-modulation by the human respiratory syncytial virus: focus on dendritic cells

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dc.article.number810
dc.catalogadorpva
dc.contributor.authorTognarelli Torres, Eduardo Ignacio
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.date.accessioned2024-01-24T19:44:03Z
dc.date.available2024-01-24T19:44:03Z
dc.date.issued2019
dc.description.abstractThe human respiratory syncytial virus (hRSV) is the leading cause of pneumonia in infants and produces a significant burden in the elderly. It can also infect and produce disease in otherwise healthy adults and recurrently infect those previously exposed to the virus. Importantly, recurrent infections are not necessarily a consequence of antigenic variability, as described for other respiratory viruses, but most likely due to the capacity of this virus to interfere with the host's immune response and the establishment of a protective and long-lasting immunity. Although some genes encoded by hRSV are known to have a direct participation in immune evasion, it seems that repeated infection is mainly given by its capacity to modulate immune components in such a way to promote non-optimal antiviral responses in the host. Importantly, hRSV is known to interfere with dendritic cell (DC) function, which are key cells involved in establishing and regulating protective virus-specific immunity. Notably, hRSV infects DCs, alters their maturation, migration to lymph nodes and their capacity to activate virus-specific T cells, which likely impacts the host antiviral response against this virus. Here, we review and discuss the most important and recent findings related to DC modulation by hRSV, which might be at the basis of recurrent infections in previously infected individuals and hRSV-induced disease. A focus on the interaction between DCs and hRSV will likely contribute to the development of effective prophylactic and antiviral strategies against this virus.
dc.fechaingreso.objetodigital2024-01-24
dc.fuente.origenConveris
dc.identifier.doi10.3389/fimmu.2019.00810
dc.identifier.eissn1664-3224
dc.identifier.issn1664-3224
dc.identifier.pubmedidMEDLINE:31057543
dc.identifier.urihttps://doi.org/10.3389/fimmu.2019.00810
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80944
dc.identifier.wosidWOS:000464550700001
dc.information.autorucFacultad de Ciencias Biológicas; Tognarelli Torres, Eduardo Ignacio; S/I; 195523
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final13
dc.pagina.inicio1
dc.revistaFrontiers in Immunologyes_ES
dc.rightsacceso abierto
dc.rights.licenseCreative Commons Attribution License (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDendritic cells (DCs)es_ES
dc.subjectDC maturationes_ES
dc.subjectAntigen presentationes_ES
dc.subjectT cell activationes_ES
dc.subjectInflammationes_ES
dc.subjectRecurrent infectiones_ES
dc.subjectImmune evasiones_ES
dc.subjectImmunityes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImmune-modulation by the human respiratory syncytial virus: focus on dendritic cellses_ES
dc.typeartículo de revisión
dc.volumen10
sipa.codpersvinculados195523
sipa.codpersvinculados113541
sipa.codpersvinculados15616
sipa.trazabilidadConveris;20-07-2021
sipa.trazabilidadORCID;2024-01-15
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