Mechanical fragmentation and pharmacologic thrombolysis in massive pulmonary embolism

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dc.contributor.authorFava, M
dc.contributor.authorLoyola, S
dc.contributor.authorFlores, P
dc.contributor.authorHuete, I
dc.date.accessioned2024-01-10T12:06:35Z
dc.date.available2024-01-10T12:06:35Z
dc.date.issued1997
dc.description.abstractPURPOSE: To evaluate the usefulness of mechanical fragmentation associated with intrapulmonary thrombolysis in acute massive pulmonary embolism (PE).
dc.description.abstractPATIENTS AND METHODS: Sixteen cases of massive PE treated with mechanical fragmentation associated with pharmacologic thrombolysis were retrospectively studied. Severity of PE was assessed with the angiographic index according to the Urokinase Pulmonary Embolism Trial (maximum value of 18; score according to whether obstruction was central or peripheral, complete or partial). Mechanical fragmentation of the emboli was performed with angiographic catheters and angioplasty balloons, Urokinase was infused directly into the thrombus during the course of 8-24 hours. The effect of therapy was measured with direct pulmonary artery pressure (PAP) and blood O-2 values.
dc.description.abstractRESULTS: Pre- and postinfusion ansographic index mean values (+/- standard deviation) were 13.7 +/- 1.4 and 6.1 +/- 2.2 (P <.0001). Mean pre- and postinfusion PAPs were 48.2 +/- 13.4 and 18.5 +/- 7.2 mm Hg (P <.0001). PaO2 increased from 60.1 +/- 12.1 to 88.7 +/- 23.4 mm Hg (P =.01). Fourteen patients (87.5%) completely recovered. One patient died during treatment despite improvement in PAP and PaO2 parameters. There were no major hemorrhagic complications.
dc.description.abstractCONCLUSIONS: The data support the efficacy of mechanical fragmentation associated with pharmacologic thrombolysis in the treatment of acute massive PE, resulting in improved hemodynamics and blood oxygenation and in decreased PAP, with low morbidity.
dc.fechaingreso.objetodigital2024-04-11
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S1051-0443(97)70552-9
dc.identifier.issn1051-0443
dc.identifier.pubmedidMEDLINE:9083994
dc.identifier.urihttps://doi.org/10.1016/S1051-0443(97)70552-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76181
dc.identifier.wosidWOS:A1997WP05100017
dc.information.autorucMedicina;Fava M;S/I;52076
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final266
dc.pagina.inicio261
dc.publisherLIPPINCOTT-RAVEN PUBL
dc.revistaJOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
dc.rightsacceso restringido
dc.subjectembolism, pulmonary
dc.subjectthrombolysis
dc.subjecturokinase
dc.subjectPERCUTANEOUS CATHETER FRAGMENTATION
dc.subjectPLASMINOGEN-ACTIVATOR
dc.subjectCLOT FRAGMENTATION
dc.subjectSTREPTOKINASE
dc.subjectEMBOLECTOMY
dc.subjectUROKINASE
dc.subjectTHERAPY
dc.subjectDEVICE
dc.subjectDISPERSION
dc.subjectEFFICACY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMechanical fragmentation and pharmacologic thrombolysis in massive pulmonary embolism
dc.typeartículo
dc.volumen8
sipa.codpersvinculados52076
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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