Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure
dc.contributor.author | Luis Winter, Jose | |
dc.contributor.author | Castro, Pablo | |
dc.contributor.author | Meneses, Luis | |
dc.contributor.author | Chalhub, Monica | |
dc.contributor.author | Verdejo, Hugo | |
dc.contributor.author | Greig, Douglas | |
dc.contributor.author | Gabrielli, Luigi | |
dc.contributor.author | Chiong, Mario | |
dc.contributor.author | Concepcion, Roberto | |
dc.contributor.author | Mellado, Rosemarie | |
dc.contributor.author | Hernandez, Claudia | |
dc.contributor.author | Uribe, Sergio | |
dc.contributor.author | Lavander, Sergio | |
dc.date.accessioned | 2024-01-10T12:06:49Z | |
dc.date.available | 2024-01-10T12:06:49Z | |
dc.date.issued | 2010 | |
dc.description.abstract | Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (creatine phosphate/ creatine transporter). Magnetic resonance (MR) imaging allows a direct and noninvasive assessment of myocardial metabolites. Aim: To measure myocardial creatine and lipids by MR spectroscopy among patients with HE Material and Methods: Cardiac MR spectroscopy (1.5 Tesla) with Hydrogen antenna and single voxel acquisition was performed in five patients with non-ischemic heart failure, aged 58 +/- 9.7 years, (60% males) and 5 healthy volunteers matched for age and sex. We analyzed the signals of creatine (Cr), lipids (L) and water (W) in the interventricular septum, establishing the water/lipid (W/L) and water/creatine (W/Cr) index to normalize the values obtained. Results: Among patients, left ventricular ejection fraction was 32 +/- 6.9%, 60% were in functional capacity II, 60% had hypertension and one was diabetic. Spectroscopic curves showed a depletion of total Cr, evidenced by the W/Cr index, among patients with heart failure, when compared with healthy controls (1.46 +/- 1.21 and 5.96 +/- 2.25 respectively, p < 0,05). Differences in myocardial lipid content, measured as the W/L index, were not significant (5.06 +/- 2.66 and 1.80 +/- 1.62 respectively, p = 0.08). Conclusions: Among patients with heart failure of non-ischemic etiology, there is a depletion of creatine levels measured by MR spectroscopy. (Rev Med Chile 2010; 138: 1475-1479). | |
dc.fechaingreso.objetodigital | 2024-06-14 | |
dc.format.extent | 5 páginas | |
dc.fuente.origen | WOS | |
dc.identifier.doi | 10.4067/S0034-98872010001300001 | |
dc.identifier.eissn | 0717-6163 | |
dc.identifier.issn | 0034-9887 | |
dc.identifier.pubmedid | MEDLINE:21526294 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/76210 | |
dc.identifier.wosid | WOS:000286684600001 | |
dc.information.autoruc | Medicina;Douglas Greig;S/I;15418 | |
dc.information.autoruc | Medicina;Hugo Verdejo;S/I;1001175 | |
dc.information.autoruc | Medicina;José Luis Winter;S/I;15983 | |
dc.information.autoruc | Medicina;Luigi Gabrielli;S/I;11086 | |
dc.information.autoruc | Medicina;Luis Meneses;S/I;10742 | |
dc.information.autoruc | Medicina;Pablo Castro;S/I;100212 | |
dc.information.autoruc | Química;Rosemarie Mellado;S/I;109357 | |
dc.information.autoruc | Medicina;Sergio Uribe;S/I;16572 | |
dc.issue.numero | 12 | |
dc.language.iso | es | |
dc.nota.acceso | contenido parcial | |
dc.pagina.final | 1479 | |
dc.pagina.inicio | 1475 | |
dc.publisher | SOC MEDICA SANTIAGO | |
dc.revista | REVISTA MEDICA DE CHILE | |
dc.rights | acceso restringido | |
dc.subject | Creatine | |
dc.subject | Heart failure | |
dc.subject | Magnetic resonance spectroscopy | |
dc.subject | CARDIOMYOPATHY | |
dc.subject | DEPLETION | |
dc.subject | KINASE | |
dc.subject.ods | 03 Good Health and Well-being | |
dc.subject.odspa | 03 Salud y bienestar | |
dc.title | Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure | |
dc.type | artículo | |
dc.volumen | 138 | |
sipa.codpersvinculados | 15418 | |
sipa.codpersvinculados | 1001175 | |
sipa.codpersvinculados | 15983 | |
sipa.codpersvinculados | 11086 | |
sipa.codpersvinculados | 10742 | |
sipa.codpersvinculados | 100212 | |
sipa.codpersvinculados | 109357 | |
sipa.codpersvinculados | 16572 | |
sipa.index | WOS | |
sipa.index | Scopus | |
sipa.trazabilidad | Carga SIPA;09-01-2024 |
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