Visible light-induced photooxidation of glucose sensitized by riboflavin

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dc.contributor.authorSilva, E
dc.contributor.authorEdwards, AM
dc.contributor.authorPacheco, D
dc.date.accessioned2024-01-10T14:22:25Z
dc.date.available2024-01-10T14:22:25Z
dc.date.issued1999
dc.description.abstractNe conducted this study to evaluate the oxidation of glucose induced by visible light in the presence of sensitizers such as methylene blue and flavins (i.e., flavin mononucleotide and riboflavin). The concentration of the sensitizers was similar to that of flavin in parenteral nutrients. The photooxidation of glucose sensitized by flavin mononucleotide or riboflavin was greater than that which was observed in the presence of methylene blue, whereas the isotopic effect of deuterium oxide (D2O) was enhanced more substantially in the presence of methylene blue than in the presence of flavins. These results show that methylene blue exerts its action through singlet oxygen and that at a high substrate concentration las was used in this work flavin mononucleotide and riboflavin act preferentially, as type I sensitizers. In the flavin photosensitized processes, the presence of hydrogen peroxide, superoxide anion, and hydroxyl radical was demonstrated. The photooxidation of glucose is favored by an increase in PH, and it also depends on the energy absorbed by the system. By using a specific reagent for glucose (i.e., o-toluidine), it was possible to quantify the photoconversion of glucose. The results obtained in this work should be considered in the management of glucose-containing parenteral nutrients that are exposed to risible light in the presence of a multivitamin complex containing flavin mononucleotide. (C) Elsevier Science Inc. 1999. All rights reserved.
dc.fechaingreso.objetodigital2024-04-11
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0955-2863(98)00093-X
dc.identifier.issn0955-2863
dc.identifier.pubmedidMEDLINE:15539287
dc.identifier.urihttps://doi.org/10.1016/S0955-2863(98)00093-X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79932
dc.identifier.wosidWOS:000078988700008
dc.information.autorucQuímica;Edwards A;S/I;53657
dc.information.autorucQuímica;Silva E;S/I;98771
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final185
dc.pagina.inicio181
dc.publisherELSEVIER SCIENCE INC
dc.revistaJOURNAL OF NUTRITIONAL BIOCHEMISTRY
dc.rightsacceso restringido
dc.subjectriboflavin
dc.subjectglucose
dc.subjectphotosensitized
dc.subjectphotooxidation
dc.subjectSINGLET MOLECULAR-OXYGEN
dc.subjectLIFETIME
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleVisible light-induced photooxidation of glucose sensitized by riboflavin
dc.typeartículo
dc.volumen10
sipa.codpersvinculados53657
sipa.codpersvinculados98771
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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