<i>N</i>-Arylation of 3-Formylquinolin-2(1<i>H</i>)-ones Using Copper(II)-Catalyzed Chan-Lam Coupling
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Date
2022
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Abstract
3-formyl-2-quinolones have attracted the scientific community's attention because they are used as versatile building blocks in the synthesis of more complex compounds showing different and attractive biological activities. Using copper-catalyzed Chan-Lam coupling, we synthesized 32 new N-aryl-3-formyl-2-quinolone derivatives at 80 degrees C, in air and using inexpensive phenylboronic acids as arylating agents. 3-formyl-2-quinolones and substituted 3-formyl-2-quinolones can act as substrates, and among the products, the p-methyl derivative 9a was used as a substrate to obtain different derivatives such as alcohol, amine, nitrile, and chalcone.
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Keywords
Chan-Lam coupling, copper(II), N-arylation, 3-formylquinolones