A short cervix in women with preterm labor and intact membranes: A risk factor for microbial invasion of the amniotic cavity
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Date
2005
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Volume Title
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MOSBY-ELSEVIER
Abstract
Objective: The purpose of this study was to determine whether there was a relationship between sonographic cervical length and the presence of culture-proven microbial invasion of the ammotic cavity in women with preterm labor and intact membranes.
Study design: Ultrasonography and amniocentesis were performed in 401 patients admitted with preterm labor (22-35 weeks) and cervical dilatation of less than or equal to 3 cm. as assessed by digital examination. Cervical length was determined by transvaginal ultrasound at admission. Outcome variables were the presence of microbial invasion of the amniotic cavity (defined as a positive amniotic fluid culture) and the occurrence of preterm delivery before 35 weeks. Contingency tables x(2) test, receiver-operator characteristic (ROC) curves, and logistic regression were used for statistical analysis.
Results: The prevalence of microbial invasion of the amniotic cavity was 7% (28/401). Spontaneous preterm delivery (less than or equal to 35 weeks) occurred in 21.4% (82/384) of patients. ROC curve analysis showed a significant relationship between the frequency of microbial invasion of the ammotic cavity and the length of the uterine cervix (area under the curve: 0.77; P <.005). Patients with a cervical length < 15 mm had a higher rate of a positive ammotic fluid culture than patients with a cervical length greater than or equal to 15 mm (26.3% [15/57] vs. 3.8% [13/344], respectively; P <.05). Moreover, patients with a short cervix (defined as < 15 mm) were more likely to deliver spontaneously before 35 weeks, 32 weeks, within 7 days, and within 48 hours of admission (P <.05 for all comparisons). Forty percent of patients (161/401) had a cervical length 30 mm. These patients had a very low risk of microbial invasion of the ammotic cavity (1.9% [3/161]), spontaneous delivery less than or equal to 35 weeks (4.5% [7/154]),less than or equal to 32 weeks (2.6% [2/76]), within 7 days (1.9% [3/154]), and within 48 hours (0% [0/154]) of admission.
Conclusion: Endovaginal ultrasonographic examination of the uterine cervix in women with preterm labor identifies patients at increased risk for intrauterine infection. (C) 2005 Elsevier Inc. All rights reserved.
Study design: Ultrasonography and amniocentesis were performed in 401 patients admitted with preterm labor (22-35 weeks) and cervical dilatation of less than or equal to 3 cm. as assessed by digital examination. Cervical length was determined by transvaginal ultrasound at admission. Outcome variables were the presence of microbial invasion of the amniotic cavity (defined as a positive amniotic fluid culture) and the occurrence of preterm delivery before 35 weeks. Contingency tables x(2) test, receiver-operator characteristic (ROC) curves, and logistic regression were used for statistical analysis.
Results: The prevalence of microbial invasion of the amniotic cavity was 7% (28/401). Spontaneous preterm delivery (less than or equal to 35 weeks) occurred in 21.4% (82/384) of patients. ROC curve analysis showed a significant relationship between the frequency of microbial invasion of the ammotic cavity and the length of the uterine cervix (area under the curve: 0.77; P <.005). Patients with a cervical length < 15 mm had a higher rate of a positive ammotic fluid culture than patients with a cervical length greater than or equal to 15 mm (26.3% [15/57] vs. 3.8% [13/344], respectively; P <.05). Moreover, patients with a short cervix (defined as < 15 mm) were more likely to deliver spontaneously before 35 weeks, 32 weeks, within 7 days, and within 48 hours of admission (P <.05 for all comparisons). Forty percent of patients (161/401) had a cervical length 30 mm. These patients had a very low risk of microbial invasion of the ammotic cavity (1.9% [3/161]), spontaneous delivery less than or equal to 35 weeks (4.5% [7/154]),less than or equal to 32 weeks (2.6% [2/76]), within 7 days (1.9% [3/154]), and within 48 hours (0% [0/154]) of admission.
Conclusion: Endovaginal ultrasonographic examination of the uterine cervix in women with preterm labor identifies patients at increased risk for intrauterine infection. (C) 2005 Elsevier Inc. All rights reserved.
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Keywords
uterine cervix, ultrasound, chorioamnionitis, amniocentesis, preterm delivery, BLOOD-CELL COUNT, FETAL INFLAMMATORY RESPONSE, WHITE-MATTER LESIONS, IMMEDIATE POSTPARTUM TREATMENT, POLYMERASE-CHAIN-REACTION, UMBILICAL-CORD PLASMA, C-REACTIVE PROTEIN, INTRAUTERINE INFECTION, UREAPLASMA-UREALYTICUM, INTRAAMNIOTIC INFECTION